Synovial fluid tests with leukocyte esterase strips improved periprosthetic joint infection detection
Source — Orthosupersite
A prospective cohort study showed that leukocyte esterase reagent strips can play an important role in the rapid diagnosis of periprosthetic joint infection when following patients after total joint arthroplasty.
“LE [leukocyte esterase] is a very accurate test for diagnosing PJI [periprosthetic joint infection],” Parvizi said at the American Academy of Orthopaedic Surgeons 2012 Annual Meeting, here.
LE at 2-plus had 100% positive predictive value and 100% specificity. I am not aware of a single test in our armamentarium today that carries the same specificity and positive predictive value,” he said, noting the strips, which are commercially available, cost about 25 cents each and can detect PJI in about 1 minute.
Source — e! Science News
New research presented at the 2012 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS) highlights the benefits of total knee replacement (TKR) in elderly patients with osteoarthritis, including a lower probability of heart failure and mortality.
There were significant positives in the osteoarthritis TKR group: the risk of mortality was half that of the non-TKR group and the congestive heart failure rate also was lower, at three, five and seven years after surgery. There was no difference in diabetes rates among both groups. Depression rates were slightly higher in the TKR group during the first three years after surgery, though there was no difference at five and seven years.
In the race to create longer-lasting and less-painful artificial joints, University of Alabama at Birmingham researchers are exploring whether nanodiamond coatings can reduce wear on joints made of metal alloys. The work is important because, according to the American Academy of Orthopedic Surgeons, more than 418,000 knee replacements and 328,000 hip replacements are performed in the United States each year; the numbers are expected to balloon as the nation’s population ages.
Joint wear generates debris that can cause pain, limit mobility and hasten joint failure. Debris particles from metal surfaces are absorbed by scavenging immune cells called macrophages, which then secrete chemicals that cause swelling and pain. This inflammation turns on bone-eating cells near implants, and bone-loss increases the likelihood implants will break loose and require a second surgery.